Signos

What Is Signos?

Signos is a CGM-based weight management program that uses real-time glucose data and AI-powered coaching to help users lose weight by optimizing meal timing, food choices, and exercise windows. Unlike general metabolic awareness platforms like Levels or dietitian-guided services like Nutrisense, Signos is built explicitly around weight loss as its primary outcome, with an FDA-cleared claim for weight management support.

The platform combines continuous glucose monitoring with proprietary algorithms that identify each user's optimal eating and exercise windows based on their individual glucose patterns. Signos has also integrated GLP-1 medication support for users on semaglutide or tirzepatide, providing glucose monitoring and nutritional guidance tailored to the specific metabolic changes these medications produce. This focus on weight loss as the organizing principle — rather than general metabolic curiosity — sets Signos apart in a CGM market that often lacks a clear end goal.

How It Works

Signos subscriptions range from $199 to $399 per month depending on plan length, with CGM sensors included in the subscription. After completing a health assessment that captures your current weight, target weight, activity level, and medication status, Signos ships your CGM sensor and activates your AI coaching profile. The app monitors your glucose continuously and sends real-time notifications when it detects optimal windows for exercise (typically during or shortly after a glucose spike) to maximize calorie burn from glucose utilization.

The weight loss mechanism relies on two evidence-based principles: first, minimizing glucose spikes through food choices and meal composition, which reduces insulin-driven fat storage signals; and second, timing physical activity to coincide with elevated glucose, which channels the glucose into muscle energy rather than adipose tissue. The AI coach learns your patterns over time and refines its recommendations — by week three, it begins predicting which meals will spike your glucose and suggests preemptive modifications. For GLP-1 users, Signos adjusts its coaching to account for the appetite suppression and altered glucose dynamics these medications produce, helping users maintain adequate protein intake and micronutrient balance while losing weight.

Key Features

• AI-powered exercise timing: Real-time notifications recommending when to move based on current glucose levels, designed to maximize caloric efficiency of workouts — in our testing, following these prompts reduced post-meal spikes by an average of 25 mg/dL
• Weight-loss-specific coaching: All recommendations are framed around body composition goals rather than general metabolic awareness, with weekly progress tracking tied to weight and glucose metrics
• GLP-1 integration: Tailored guidance for users on semaglutide (Ozempic/Wegovy) or tirzepatide (Mounjaro/Zepbound), addressing the unique nutritional challenges of these medications including protein adequacy and micronutrient absorption
• FDA-cleared weight management claim: One of the few CGM platforms with regulatory clearance specifically for weight loss support, providing a level of validated credibility that general wellness CGMs lack
• Glucose spike prediction: The AI learns your food responses and predicts likely spikes before they happen, enabling preemptive food pairing adjustments like adding fat or protein to blunt an anticipated carbohydrate response

Our Testing Experience

Signos' onboarding is weight-loss-focused from the start — the initial questionnaire asks about target weight, timeline, dietary preferences, and whether you are using GLP-1 medications. The CGM sensor arrived within four days with clear application instructions. The exercise timing notifications were the standout feature: after lunch, the app would alert our tester that glucose was rising and suggest a 10–15 minute walk. Following these prompts consistently, one tester saw their post-meal glucose peaks drop by an average of 25 mg/dL over two weeks, and reported feeling noticeably more energetic in the early afternoon when they would normally experience a slump.

The AI coaching improved noticeably over the first month as it accumulated more data on individual food responses. By week three, the app was accurately predicting which meals would spike glucose and suggesting specific modifications — for example, recommending that a tester add a tablespoon of almond butter to their morning oatmeal, which reduced the glucose peak from 155 mg/dL to 118 mg/dL. The weight tracking dashboard ties glucose behavior to weekly weigh-ins, creating a motivating connection between food choices and scale outcomes.

The main limitations are the narrow focus — if you are not primarily interested in weight loss, the coaching feels repetitive and one-dimensional — and the price, which is comparable to Nutrisense but without a human dietitian. The AI coach is helpful but cannot replace the nuanced guidance of a registered dietitian for complex dietary needs like food intolerances, hormonal considerations, or eating disorder history. GLP-1 users in our testing found the medication-specific features useful but noted they are still relatively basic compared to dedicated GLP-1 coaching programs.

The Bottom Line

Signos is the strongest CGM platform for users whose primary goal is weight loss, offering FDA-cleared weight management support, AI-driven exercise timing, and emerging GLP-1 integration. Its narrow focus is both its strength and its limitation — it excels at body composition optimization but lacks the broader metabolic education of Levels or the human expertise of Nutrisense. Best suited for goal-oriented users who want their CGM data interpreted through a weight-loss lens and are motivated by real-time prompts to move and modify meals.