NOVOS Core
A 12-ingredient longevity formula targeting multiple hallmarks of aging in one drink mix. Developed with input from Harvard and MIT longevity scientists. Third-party tested, transparent dosing.
Our Verdict
The best all-in-one longevity formula for people who would rather take one transparent, well-designed blend than build a 10-bottle stack. Multi-hallmark approach, disclosed dosing, third-party tested. The 12-ingredient combination itself is unproven as a whole — but the parts are credible and the convenience is real.
Last updated: July 2026
Affiliate Disclosure: BetterVitals may earn a commission from purchases made through links in this article, at no additional cost to you. This supports our independent research and analysis. We only recommend products we believe in after thorough evaluation.
Pros
- Targets multiple hallmarks of aging rather than a single pathway
- Fully transparent, disclosed dosing — no proprietary blends
- Third-party tested with published results
- Developed with input from Harvard- and MIT-affiliated longevity researchers
- One daily drink mix replaces a large multi-supplement stack
Cons
- The specific 12-ingredient blend is unproven as a whole in independent trials
- Premium price at ~$109/month
- No NAD+ precursor included (sold separately as NOVOS Boost)
- Efficacy evidence leans on individual ingredients plus a brand-sponsored study
- Drink-mix format and taste are not for everyone
Best For
- People who want one comprehensive longevity supplement instead of a large stack
- Those who value transparent, fully-disclosed dosing and third-party testing
- Biohackers interested in multi-hallmark aging targets (Ca-AKG, fisetin, glycine)
- Anyone who finds assembling and timing separate supplements impractical
Not Ideal For
- Budget buyers — $109/month is a premium for a daily foundational product
- People who want a single-molecule product with dedicated trial evidence
- Anyone expecting noticeable short-term effects (this is long-game support)
- Those who prefer to buy each ingredient separately and control their own doses
In-Depth Review
What It Is
NOVOS Core is a comprehensive longevity formula — not a single-molecule product but a 12-ingredient blend designed to address several of the recognized "hallmarks of aging" at once: DNA damage, cellular senescence, mitochondrial decline, and glycation. Ingredients include calcium alpha-ketoglutarate (Ca-AKG), glycine, glucosamine, fisetin, pterostilbene, lithium (microdose), magnesium, ginger, and others, delivered as a once-daily drink mix.
NOVOS positions itself as science-first: the formula was developed with input from longevity researchers affiliated with Harvard and MIT, every ingredient and dose is disclosed (no proprietary blends), and the company publishes third-party test results. That transparency is genuinely above average for the category.
Why a Blend Instead of a Single Molecule
Aging isn't driven by one pathway, so NOVOS's thesis is that a multi-target approach beats chasing NAD+ alone. Several Core ingredients have individual human or strong preclinical support — Ca-AKG and glycine both have longevity-relevant data, fisetin is a well-known senolytic candidate, and pterostilbene is a more bioavailable resveratrol analog. The trade-off is that no one has run a clinical trial on this specific 12-ingredient combination, so you're trusting the sum of the parts rather than a tested whole.
What to Expect
Core is a foundational daily supplement, not a stimulant — most people won't "feel" it. NOVOS has published a small brand-sponsored study suggesting the formula reduced markers of cellular aging and improved skin parameters. Treat brand studies with appropriate caution, but the underlying ingredient rationale is more credible than most all-in-one longevity products.
Interested in NOVOS Core?
Check the latest pricing and availability from the official store.
View Best PriceThe Bottom Line
NOVOS Core is our top pick for someone who wants one longevity supplement that covers multiple bases with transparent, disclosed dosing rather than assembling a 10-bottle stack themselves. At ~$109/month it's not cheap, but replicating the formula ingredient-by-ingredient would cost more. The honest caveat: the specific blend is unproven as a whole, and you're paying for convenience and formulation quality.
Research & Evidence
Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice
Cell Metabolism
Calcium alpha-ketoglutarate (a core NOVOS ingredient) extended lifespan and, more notably, compressed the period of late-life morbidity in aged mice.
View on PubMedFisetin is a senotherapeutic that extends health and lifespan
EBioMedicine
Fisetin reduced senescent cell burden in multiple tissues and extended median and maximum lifespan in mice, supporting its inclusion as a senolytic candidate.
View on PubMedEffect of a multi-ingredient supplement on markers of cellular aging
NOVOS Labs / Brand-Sponsored Study
A brand-sponsored evaluation reported the Core formula reduced select markers of cellular aging and improved skin parameters; independent replication is lacking.
Frequently Asked Questions
Common questions about this topic
Ready to try NOVOS Core?
See the latest pricing and availability.
View Best PriceAffiliate link - we may earn a commission
Compare NOVOS Core
See how NOVOS Core stacks up against the competition
Related Products
Links may be affiliate links